Stephanie McLean How CosmedIQ™’s New XODerm Exosomes Enhance Skin Repair and Rejuvenation
Launching at the upcoming COSMEDICON conference, CosmedIQ™ is set to lead the way in exosome innovation with their latest product XODerm. This umbilical-derived exosome is specifically designed for advanced skin regeneration, harnessing the power of Wharton’s Jelly-derived mesenchymal stem cells (MSCs) to support repair, rejuvenation, and anti-ageing benefits.
What is Wharton’s Jelly?
Wharton’s Jelly, a gelatinous connective tissue within the umbilical cord, not only protects the umbilical vessels but also serves as a potent source of growth factors, extracellular vesicles (exosomes), cytokines, and proteins essential for regeneration and repair. These bioactive components enhance collagen production, accelerate tissue healing, and provide exceptional regenerative benefits. Unlike other stem cell sources that decline in function with age, Wharton’s Jelly-derived mesenchymal stem cells (MSCs) remain youthful and highly effective for regenerative medicine. Furthermore, its collection is ethically sourced, ensuring a responsible and sustainable approach to regenerative therapies.
How do XO DERM exosomes improve skin regeneration compared to other sources?
With their unique biological properties and exceptional regenerative potential, XODerm exosomes are set to become a leading choice in regenerative medicine. Compared to exosomes from adipose tissue or bone marrow, those derived from Wharton’s Jelly offer superior regenerative signalling, thanks to their higher concentration of growth factors and immune-modulatory molecules. This allows them to reduce inflammation at wound sites, creating an optimal environment for tissue repair while minimising the risk of excessive scarring. This is especially important in skin regeneration, where controlling inflammation is key to achieving aesthetic and functional healing. XODerm also shows lower immunogenicity, reducing the risk of immune rejection or adverse reactions.
What role does bFGF (Basic Fibroblast Growth Factor ) play in boosting exosome activity and long-term skin benefits?
Human pluripotent stem cells are a critical source for cell therapy products, but they require growth factors like basic fibroblast growth factor (bFGF) to maintain their regenerative ability. Unfortunately, bFGF has a short half-life in cell culture, making it challenging to maintain a continuous supply for high-quality stem cells. To solve this, XODerm has a thermo-stable bFGF that maintains its activity over a longer period, improving stem cell proliferation, stemness, and differentiation.
In the context of exosome production, thermo-stable bFGF plays a key role in the manufacturing process by enhancing the activity and efficacy of exosomes. When incorporated into exosomes, it helps improve their cargo delivery to skin cells, promoting collagen production, angiogenesis, and wound healing. The stability of the bFGF ensures it remains biologically active throughout storage and processing, enabling long-lasting regenerative effects in skin treatments. This results in sustained skin benefits such as improved skin texture, elasticity, and reduced scarring. By maintaining the potency of bFGF during manufacturing, this process enhances the effectiveness of exosome-based therapies, ensuring long-term skin rejuvenation. XODerm is the only product on the market World Wide the uses stable bFGF to generate stable exosomes – ensuring you have active and potent exosomes on use.
How does the smaller particle size and higher anti-inflammatory activity improve absorption and efficacy?
The smaller particle size of XODerm exosomes, combined with their high anti-inflammatory activity, enhances absorption and efficacy in skin regeneration and other therapeutic applications. Their compact size allows for seamless penetration of cellular membranes, ensuring efficient cellular uptake. This enables exosomes to traverse skin barriers and reach deeper tissue layers, effectively delivering bioactive molecules—such as growth factors, miRNA, and proteins—directly to target cells like fibroblasts, keratinocytes, and endothelial cells, maximizing their regenerative impact.
Their size also enables them to travel through the interstitial space more easily, improving distribution within the skin and surrounding tissues, thereby increasing the efficacy of treatments, such as skin regeneration, wound healing, and anti-ageing therapies.
Additionally, the smaller size of XODerm exosomes also allows them to easily interact with cell surface receptors, facilitating direct communication and signalling between the exosome and the target cell. This precise targeting improves the efficacy of treatments, ensuring that the therapeutic molecules within the exosomes are delivered effectively and directly to the desired tissues, leading to faster, more noticeable healing and skin rejuvenation.
With a biocompatible lipid bilayer structure and natural origin, XODerm exosomes minimise the risk of immune rejection, making them safe for long-term use. Their high anti-inflammatory activity further enhances wound healing and regeneration, creating an optimal environment for tissue repair while reducing inflammation and maximizing absorption of regenerative factors.
How can XODerm exosomes be combined with treatments like microneedling, RF, and lasers for better results?
Combining XODerm therapy with microneedling, radiofrequency (RF), and laser treatments creates a powerful synergistic effect for skin regeneration and rejuvenation. These treatments work by creating micro-channels or delivering controlled heat to stimulate collagen remodelling and skin resurfacing. When paired with exosomes, the healing process is accelerated, inflammation is reduced, and overall skin regeneration is enhanced.
The anti-inflammatory properties of XODerm exosomes support faster recovery, minimising redness, swelling, and the risk of post-treatment complications like scarring or pigmentation issues. This makes procedures more comfortable, with less downtime and improved treatment outcomes.
This combination leads to longer-lasting benefits such as improved skin texture, firmness, elasticity, and overall radiance. Additionally, exosomes optimize the effects of these therapies, ensuring maximum collagen production, smoother skin, and a more youthful appearance with sustained results.
What is the price of XODerm Exosomes, and where can we learn more about them?
With many exosome products priced over $150 per vial, XODerm offers a more accessible option at $70 per vial at the time of printing. This competitive pricing makes it an excellent choice for clinics looking to integrate regenerative medicine seamlessly into their practice.
Join Professor Shin from South Korea at COSMEDICON this Saturday at 2:30 PM as he explores the next generation of exosomes. In his session, “How Thermostable Basic Fibroblast Growth Factor Secures High-Quality Stem Cells and Enhances Production and Activity of Human MSC-Derived Exosomes,” he will discuss the latest advancements in regenerative medicine, with a special focus on XODerm Exosomes.
Learn more by visiting: https://xoderm.com.au/
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